COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups
Identifieur interne : 004806 ( Main/Exploration ); précédent : 004805; suivant : 004807COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups
Auteurs : Perminder S. Sachdev [Australie] ; Darren M. Lipnicki [Australie] ; Nicole A. Kochan [Australie] ; John D. Crawford [Australie] ; Kenneth Rockwood [Canada] ; Shifu Xiao [République populaire de Chine] ; Juan Li [République populaire de Chine] ; Xia Li [République populaire de Chine] ; Carol Brayne [Royaume-Uni] ; Fiona E. Matthews [Royaume-Uni] ; Blossom Cm Stephan [Royaume-Uni] ; Richard B. Lipton [États-Unis] ; Mindy J. Katz [États-Unis] ; Karen Ritchie [France, Royaume-Uni] ; Isabelle Carrière [France] ; Marie-Laure Ancelin [France] ; Sudha Seshadri [États-Unis] ; Rhoda Au [États-Unis] ; Alexa S. Beiser [États-Unis] ; Linda Cw Lam [République populaire de Chine] ; Candy Hy Wong [République populaire de Chine] ; Ada Wt Fung [République populaire de Chine] ; Ki Woong Kim [Corée du Sud] ; Ji Won Han [Corée du Sud] ; Tae Hui Kim [Corée du Sud] ; Ronald C. Petersen [États-Unis] ; Rosebud O. Roberts [États-Unis] ; Michelle M. Mielke [États-Unis] ; Mary Ganguli [États-Unis] ; Hiroko H. Dodge [États-Unis] ; Tiffany Hughes [États-Unis] ; Kaarin J. Anstey [Australie] ; Nicolas Cherbuin [Australie] ; Peter Butterworth [Australie] ; Tze Pin Ng [Singapour] ; Qi Gao [Singapour] ; Simone Reppermund [Australie] ; Henry Brodaty [Australie] ; Kenichi Meguro [Japon] ; Nicole Schupf [États-Unis] ; Jennifer Manly [États-Unis] ; Yaakov Stern [États-Unis] ; Antonio Lobo [Espagne] ; Raúl Lopez-Anton [Espagne] ; Javier Santabárbara [Espagne]Source :
- BMC Neurology [ 1471-2377 ] ; 2013.
Abstract
A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.
Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress.
The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing.
Url:
DOI: 10.1186/1471-2377-13-165
PubMed: 24195705
PubMed Central: 3827845
Affiliations:
- Australie, Canada, Corée du Sud, Espagne, France, Japon, Royaume-Uni, République populaire de Chine, Singapour, États-Unis
- Angleterre, Aragon (communauté autonome), Communauté de Madrid, Grand Londres, Languedoc-Roussillon, Massachusetts, Michigan, Minnesota, Nouvelle-Galles du Sud, Occitanie (région administrative), Oregon, Pennsylvanie, Région capitale de Séoul, État de New York
- Londres, Madrid, Montpellier, New York, Pékin, Saragosse, Sha Tin, Sydney, Séoul
- Université Columbia, Université chinoise de Hong Kong, Université de Saragosse, Université nationale de Singapour
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001605
- to stream Pmc, to step Curation: 001465
- to stream Pmc, to step Checkpoint: 001C25
- to stream Ncbi, to step Merge: 001558
- to stream Ncbi, to step Curation: 001558
- to stream Ncbi, to step Checkpoint: 001558
- to stream Main, to step Merge: 004923
- to stream Main, to step Curation: 004806
Le document en format XML
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Sachdev</name><affiliation wicri:level="3"><nlm:aff id="I1">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Dementia Collaborative Research Centre, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Dementia Collaborative Research Centre, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Lipnicki, Darren M" sort="Lipnicki, Darren M" uniqKey="Lipnicki D" first="Darren M" last="Lipnicki">Darren M. Lipnicki</name><affiliation wicri:level="3"><nlm:aff id="I1">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Kochan, Nicole A" sort="Kochan, Nicole A" uniqKey="Kochan N" first="Nicole A" last="Kochan">Nicole A. 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Korey Department of Neurology; Albert Einstein College of Medicine, Yeshiva University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I10">Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Katz, Mindy J" sort="Katz, Mindy J" uniqKey="Katz M" first="Mindy J" last="Katz">Mindy J. Katz</name><affiliation wicri:level="2"><nlm:aff id="I9">Saul B. Korey Department of Neurology; Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Saul B. 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xml:lang="fr">France</country><wicri:regionArea>Université de Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I13">Faculty of Medicine, Imperial College, St Mary’s Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, Imperial College, St Mary’s Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Carriere, Isabelle" sort="Carriere, Isabelle" uniqKey="Carriere I" first="Isabelle" last="Carrière">Isabelle Carrière</name><affiliation wicri:level="1"><nlm:aff id="I11">Inserm, U1061 Nervous System Pathologies: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061 Nervous System Pathologies: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5</wicri:regionArea><wicri:noRegion>Montpellier Cedex 5</wicri:noRegion><wicri:noRegion>Montpellier Cedex 5</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="I12">Université de Montpellier 1, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><affiliation wicri:level="1"><nlm:aff id="I11">Inserm, U1061 Nervous System Pathologies: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061 Nervous System Pathologies: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5</wicri:regionArea><wicri:noRegion>Montpellier Cedex 5</wicri:noRegion><wicri:noRegion>Montpellier Cedex 5</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="I12">Université de Montpellier 1, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><nlm:aff id="I14">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><affiliation wicri:level="2"><nlm:aff id="I14">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Beiser, Alexa S" sort="Beiser, Alexa S" uniqKey="Beiser A" first="Alexa S" last="Beiser">Alexa S. Beiser</name><affiliation wicri:level="2"><nlm:aff id="I15">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lam, Linda Cw" sort="Lam, Linda Cw" uniqKey="Lam L" first="Linda Cw" last="Lam">Linda Cw Lam</name><affiliation wicri:level="4"><nlm:aff id="I16">Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, SAR</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Wong, Candy Hy" sort="Wong, Candy Hy" uniqKey="Wong C" first="Candy Hy" last="Wong">Candy Hy Wong</name><affiliation wicri:level="1"><nlm:aff id="I17">Department of Psychiatry, Tai Po Hospital, Hong Kong, SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Psychiatry, Tai Po Hospital, Hong Kong, SAR</wicri:regionArea><wicri:noRegion>SAR</wicri:noRegion></affiliation></author><author><name sortKey="Fung, Ada Wt" sort="Fung, Ada Wt" uniqKey="Fung A" first="Ada Wt" last="Fung">Ada Wt Fung</name><affiliation wicri:level="4"><nlm:aff id="I16">Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, SAR</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Kim, Ki Woong" sort="Kim, Ki Woong" uniqKey="Kim K" first="Ki Woong" last="Kim">Ki Woong Kim</name><affiliation wicri:level="1"><nlm:aff id="I18">Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="I19">Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Psychiatry, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I20">Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Han, Ji Won" sort="Han, Ji Won" uniqKey="Han J" first="Ji Won" last="Han">Ji Won Han</name><affiliation wicri:level="1"><nlm:aff id="I18">Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Tae Hui" sort="Kim, Tae Hui" uniqKey="Kim T" first="Tae Hui" last="Kim">Tae Hui Kim</name><affiliation wicri:level="1"><nlm:aff id="I18">Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C" last="Petersen">Ronald C. Petersen</name><affiliation wicri:level="2"><nlm:aff id="I21">Mayo Clinic College of Medicine, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic College of Medicine, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Roberts, Rosebud O" sort="Roberts, Rosebud O" uniqKey="Roberts R" first="Rosebud O" last="Roberts">Rosebud O. Roberts</name><affiliation wicri:level="2"><nlm:aff id="I21">Mayo Clinic College of Medicine, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic College of Medicine, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Mielke, Michelle M" sort="Mielke, Michelle M" uniqKey="Mielke M" first="Michelle M" last="Mielke">Michelle M. Mielke</name><affiliation wicri:level="2"><nlm:aff id="I21">Mayo Clinic College of Medicine, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic College of Medicine, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Ganguli, Mary" sort="Ganguli, Mary" uniqKey="Ganguli M" first="Mary" last="Ganguli">Mary Ganguli</name><affiliation wicri:level="2"><nlm:aff id="I22">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I23">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I24">Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Dodge, Hiroko H" sort="Dodge, Hiroko H" uniqKey="Dodge H" first="Hiroko H" last="Dodge">Hiroko H. Dodge</name><affiliation wicri:level="2"><nlm:aff id="I25">Department of Neurology, Oregon Health and Science University, Portland, OR, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, OR</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I26">Department of Neurology, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Hughes, Tiffany" sort="Hughes, Tiffany" uniqKey="Hughes T" first="Tiffany" last="Hughes">Tiffany Hughes</name><affiliation wicri:level="2"><nlm:aff id="I22">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Anstey, Kaarin J" sort="Anstey, Kaarin J" uniqKey="Anstey K" first="Kaarin J" last="Anstey">Kaarin J. Anstey</name><affiliation wicri:level="1"><nlm:aff id="I27">Centre for Research on Ageing, Health and Wellbeing, College of Medicine, Biology and Environment, The Australian National University, Canberra, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Research on Ageing, Health and Wellbeing, College of Medicine, Biology and Environment, The Australian National University, Canberra</wicri:regionArea><wicri:noRegion>Canberra</wicri:noRegion></affiliation></author><author><name sortKey="Cherbuin, Nicolas" sort="Cherbuin, Nicolas" uniqKey="Cherbuin N" first="Nicolas" last="Cherbuin">Nicolas Cherbuin</name><affiliation wicri:level="1"><nlm:aff id="I27">Centre for Research on Ageing, Health and Wellbeing, College of Medicine, Biology and Environment, The Australian National University, Canberra, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Research on Ageing, Health and Wellbeing, College of Medicine, Biology and Environment, The Australian National University, Canberra</wicri:regionArea><wicri:noRegion>Canberra</wicri:noRegion></affiliation></author><author><name sortKey="Butterworth, Peter" sort="Butterworth, Peter" uniqKey="Butterworth P" first="Peter" last="Butterworth">Peter Butterworth</name><affiliation wicri:level="1"><nlm:aff id="I27">Centre for Research on Ageing, Health and Wellbeing, College of Medicine, Biology and Environment, The Australian National University, Canberra, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Research on Ageing, Health and Wellbeing, College of Medicine, Biology and Environment, The Australian National University, Canberra</wicri:regionArea><wicri:noRegion>Canberra</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Tze Pin" sort="Ng, Tze Pin" uniqKey="Ng T" first="Tze Pin" last="Ng">Tze Pin Ng</name><affiliation wicri:level="4"><nlm:aff id="I28">Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Gao, Qi" sort="Gao, Qi" uniqKey="Gao Q" first="Qi" last="Gao">Qi Gao</name><affiliation wicri:level="4"><nlm:aff id="I28">Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Reppermund, Simone" sort="Reppermund, Simone" uniqKey="Reppermund S" first="Simone" last="Reppermund">Simone Reppermund</name><affiliation wicri:level="3"><nlm:aff id="I1">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Brodaty, Henry" sort="Brodaty, Henry" uniqKey="Brodaty H" first="Henry" last="Brodaty">Henry Brodaty</name><affiliation wicri:level="3"><nlm:aff id="I1">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Dementia Collaborative Research Centre, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Dementia Collaborative Research Centre, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Meguro, Kenichi" sort="Meguro, Kenichi" uniqKey="Meguro K" first="Kenichi" last="Meguro">Kenichi Meguro</name><affiliation wicri:level="1"><nlm:aff id="I29">Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Sendai</wicri:regionArea><wicri:noRegion>Sendai</wicri:noRegion></affiliation></author><author><name sortKey="Schupf, Nicole" sort="Schupf, Nicole" uniqKey="Schupf N" first="Nicole" last="Schupf">Nicole Schupf</name><affiliation wicri:level="4"><nlm:aff id="I30">The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I31">The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Gertrude H. Sergievsky Center, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I32">The Division of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Division of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Manly, Jennifer" sort="Manly, Jennifer" uniqKey="Manly J" first="Jennifer" last="Manly">Jennifer Manly</name><affiliation wicri:level="4"><nlm:aff id="I30">The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I31">The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Gertrude H. Sergievsky Center, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I33">The Department of Neurology, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Department of Neurology, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><affiliation wicri:level="4"><nlm:aff id="I30">The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I31">The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Gertrude H. Sergievsky Center, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I33">The Department of Neurology, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Department of Neurology, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Lobo, Antonio" sort="Lobo, Antonio" uniqKey="Lobo A" first="Antonio" last="Lobo">Antonio Lobo</name><affiliation wicri:level="4"><nlm:aff id="I34">Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza</wicri:regionArea><orgName type="university">Université de Saragosse</orgName><placeName><settlement type="city">Saragosse</settlement><region nuts="2" type="region">Aragon (communauté autonome)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I35">Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I36">Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza</wicri:regionArea><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Anton, Raul" sort="Lopez Anton, Raul" uniqKey="Lopez Anton R" first="Raúl" last="Lopez-Anton">Raúl Lopez-Anton</name><affiliation wicri:level="3"><nlm:aff id="I35">Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="I37">Department of Psychology and Sociology, Universidad de Zaragoza, Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychology and Sociology, Universidad de Zaragoza, Zaragoza</wicri:regionArea><orgName type="university">Université de Saragosse</orgName><placeName><settlement type="city">Saragosse</settlement><region nuts="2" type="region">Aragon (communauté autonome)</region></placeName></affiliation></author><author><name sortKey="Santabarbara, Javier" sort="Santabarbara, Javier" uniqKey="Santabarbara J" first="Javier" last="Santabárbara">Javier Santabárbara</name><affiliation wicri:level="3"><nlm:aff id="I35">Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="I38">Department of Preventive Medicine and Public Health, Universidad de Zaragoza, Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Preventive Medicine and Public Health, Universidad de Zaragoza, Zaragoza</wicri:regionArea><orgName type="university">Université de Saragosse</orgName><placeName><settlement type="city">Saragosse</settlement><region nuts="2" type="region">Aragon (communauté autonome)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24195705</idno><idno type="pmc">3827845</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827845</idno><idno type="RBID">PMC:3827845</idno><idno type="doi">10.1186/1471-2377-13-165</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001605</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001605</idno><idno type="wicri:Area/Pmc/Curation">001465</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001465</idno><idno type="wicri:Area/Pmc/Checkpoint">001C25</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001C25</idno><idno type="wicri:Area/Ncbi/Merge">001558</idno><idno type="wicri:Area/Ncbi/Curation">001558</idno><idno type="wicri:Area/Ncbi/Checkpoint">001558</idno><idno type="wicri:Area/Main/Merge">004923</idno><idno type="wicri:Area/Main/Curation">004806</idno><idno type="wicri:Area/Main/Exploration">004806</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups</title><author><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S" last="Sachdev">Perminder S. Sachdev</name><affiliation wicri:level="3"><nlm:aff id="I1">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Dementia Collaborative Research Centre, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Dementia Collaborative Research Centre, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Lipnicki, Darren M" sort="Lipnicki, Darren M" uniqKey="Lipnicki D" first="Darren M" last="Lipnicki">Darren M. Lipnicki</name><affiliation wicri:level="3"><nlm:aff id="I1">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Kochan, Nicole A" sort="Kochan, Nicole A" uniqKey="Kochan N" first="Nicole A" last="Kochan">Nicole A. Kochan</name><affiliation wicri:level="3"><nlm:aff id="I1">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Crawford, John D" sort="Crawford, John D" uniqKey="Crawford J" first="John D" last="Crawford">John D. Crawford</name><affiliation wicri:level="3"><nlm:aff id="I1">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Rockwood, Kenneth" sort="Rockwood, Kenneth" uniqKey="Rockwood K" first="Kenneth" last="Rockwood">Kenneth Rockwood</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Medicine (Geriatric Medicine & Neurology), Dalhousie University, Halifax, NS, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine (Geriatric Medicine & Neurology), Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Xiao, Shifu" sort="Xiao, Shifu" uniqKey="Xiao S" first="Shifu" last="Xiao">Shifu Xiao</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name><affiliation wicri:level="3"><nlm:aff id="I5">Institute of Psychology, Chinese Academy of Sciences, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Psychology, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Xia" sort="Li, Xia" uniqKey="Li X" first="Xia" last="Li">Xia Li</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name><affiliation wicri:level="1"><nlm:aff id="I6">Department of Public Health and Primary Care, Cambridge University, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Public Health and Primary Care, Cambridge University, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Matthews, Fiona E" sort="Matthews, Fiona E" uniqKey="Matthews F" first="Fiona E" last="Matthews">Fiona E. Matthews</name><affiliation wicri:level="1"><nlm:aff id="I7">MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Biostatistics Unit, Institute of Public Health, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Stephan, Blossom Cm" sort="Stephan, Blossom Cm" uniqKey="Stephan B" first="Blossom Cm" last="Stephan">Blossom Cm Stephan</name><affiliation wicri:level="1"><nlm:aff id="I8">Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Health and Society, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Lipton, Richard B" sort="Lipton, Richard B" uniqKey="Lipton R" first="Richard B" last="Lipton">Richard B. Lipton</name><affiliation wicri:level="2"><nlm:aff id="I9">Saul B. Korey Department of Neurology; Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Saul B. Korey Department of Neurology; Albert Einstein College of Medicine, Yeshiva University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I10">Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Katz, Mindy J" sort="Katz, Mindy J" uniqKey="Katz M" first="Mindy J" last="Katz">Mindy J. Katz</name><affiliation wicri:level="2"><nlm:aff id="I9">Saul B. Korey Department of Neurology; Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Saul B. Korey Department of Neurology; Albert Einstein College of Medicine, Yeshiva University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="1"><nlm:aff id="I11">Inserm, U1061 Nervous System Pathologies: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061 Nervous System Pathologies: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5</wicri:regionArea><wicri:noRegion>Montpellier Cedex 5</wicri:noRegion><wicri:noRegion>Montpellier Cedex 5</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="I12">Université de Montpellier 1, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I13">Faculty of Medicine, Imperial College, St Mary’s Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, Imperial College, St Mary’s Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Carriere, Isabelle" sort="Carriere, Isabelle" uniqKey="Carriere I" first="Isabelle" last="Carrière">Isabelle Carrière</name><affiliation wicri:level="1"><nlm:aff id="I11">Inserm, U1061 Nervous System Pathologies: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061 Nervous System Pathologies: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5</wicri:regionArea><wicri:noRegion>Montpellier Cedex 5</wicri:noRegion><wicri:noRegion>Montpellier Cedex 5</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="I12">Université de Montpellier 1, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><affiliation wicri:level="1"><nlm:aff id="I11">Inserm, U1061 Nervous System Pathologies: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061 Nervous System Pathologies: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5</wicri:regionArea><wicri:noRegion>Montpellier Cedex 5</wicri:noRegion><wicri:noRegion>Montpellier Cedex 5</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="I12">Université de Montpellier 1, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><nlm:aff id="I14">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><affiliation wicri:level="2"><nlm:aff id="I14">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Beiser, Alexa S" sort="Beiser, Alexa S" uniqKey="Beiser A" first="Alexa S" last="Beiser">Alexa S. Beiser</name><affiliation wicri:level="2"><nlm:aff id="I15">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lam, Linda Cw" sort="Lam, Linda Cw" uniqKey="Lam L" first="Linda Cw" last="Lam">Linda Cw Lam</name><affiliation wicri:level="4"><nlm:aff id="I16">Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, SAR</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Wong, Candy Hy" sort="Wong, Candy Hy" uniqKey="Wong C" first="Candy Hy" last="Wong">Candy Hy Wong</name><affiliation wicri:level="1"><nlm:aff id="I17">Department of Psychiatry, Tai Po Hospital, Hong Kong, SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Psychiatry, Tai Po Hospital, Hong Kong, SAR</wicri:regionArea><wicri:noRegion>SAR</wicri:noRegion></affiliation></author><author><name sortKey="Fung, Ada Wt" sort="Fung, Ada Wt" uniqKey="Fung A" first="Ada Wt" last="Fung">Ada Wt Fung</name><affiliation wicri:level="4"><nlm:aff id="I16">Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, SAR</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Kim, Ki Woong" sort="Kim, Ki Woong" uniqKey="Kim K" first="Ki Woong" last="Kim">Ki Woong Kim</name><affiliation wicri:level="1"><nlm:aff id="I18">Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="I19">Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Psychiatry, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I20">Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Han, Ji Won" sort="Han, Ji Won" uniqKey="Han J" first="Ji Won" last="Han">Ji Won Han</name><affiliation wicri:level="1"><nlm:aff id="I18">Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Tae Hui" sort="Kim, Tae Hui" uniqKey="Kim T" first="Tae Hui" last="Kim">Tae Hui Kim</name><affiliation wicri:level="1"><nlm:aff id="I18">Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C" last="Petersen">Ronald C. Petersen</name><affiliation wicri:level="2"><nlm:aff id="I21">Mayo Clinic College of Medicine, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic College of Medicine, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Roberts, Rosebud O" sort="Roberts, Rosebud O" uniqKey="Roberts R" first="Rosebud O" last="Roberts">Rosebud O. Roberts</name><affiliation wicri:level="2"><nlm:aff id="I21">Mayo Clinic College of Medicine, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic College of Medicine, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Mielke, Michelle M" sort="Mielke, Michelle M" uniqKey="Mielke M" first="Michelle M" last="Mielke">Michelle M. Mielke</name><affiliation wicri:level="2"><nlm:aff id="I21">Mayo Clinic College of Medicine, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic College of Medicine, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Ganguli, Mary" sort="Ganguli, Mary" uniqKey="Ganguli M" first="Mary" last="Ganguli">Mary Ganguli</name><affiliation wicri:level="2"><nlm:aff id="I22">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I23">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I24">Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Dodge, Hiroko H" sort="Dodge, Hiroko H" uniqKey="Dodge H" first="Hiroko H" last="Dodge">Hiroko H. Dodge</name><affiliation wicri:level="2"><nlm:aff id="I25">Department of Neurology, Oregon Health and Science University, Portland, OR, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, OR</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I26">Department of Neurology, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Hughes, Tiffany" sort="Hughes, Tiffany" uniqKey="Hughes T" first="Tiffany" last="Hughes">Tiffany Hughes</name><affiliation wicri:level="2"><nlm:aff id="I22">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Anstey, Kaarin J" sort="Anstey, Kaarin J" uniqKey="Anstey K" first="Kaarin J" last="Anstey">Kaarin J. Anstey</name><affiliation wicri:level="1"><nlm:aff id="I27">Centre for Research on Ageing, Health and Wellbeing, College of Medicine, Biology and Environment, The Australian National University, Canberra, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Research on Ageing, Health and Wellbeing, College of Medicine, Biology and Environment, The Australian National University, Canberra</wicri:regionArea><wicri:noRegion>Canberra</wicri:noRegion></affiliation></author><author><name sortKey="Cherbuin, Nicolas" sort="Cherbuin, Nicolas" uniqKey="Cherbuin N" first="Nicolas" last="Cherbuin">Nicolas Cherbuin</name><affiliation wicri:level="1"><nlm:aff id="I27">Centre for Research on Ageing, Health and Wellbeing, College of Medicine, Biology and Environment, The Australian National University, Canberra, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Research on Ageing, Health and Wellbeing, College of Medicine, Biology and Environment, The Australian National University, Canberra</wicri:regionArea><wicri:noRegion>Canberra</wicri:noRegion></affiliation></author><author><name sortKey="Butterworth, Peter" sort="Butterworth, Peter" uniqKey="Butterworth P" first="Peter" last="Butterworth">Peter Butterworth</name><affiliation wicri:level="1"><nlm:aff id="I27">Centre for Research on Ageing, Health and Wellbeing, College of Medicine, Biology and Environment, The Australian National University, Canberra, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Research on Ageing, Health and Wellbeing, College of Medicine, Biology and Environment, The Australian National University, Canberra</wicri:regionArea><wicri:noRegion>Canberra</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Tze Pin" sort="Ng, Tze Pin" uniqKey="Ng T" first="Tze Pin" last="Ng">Tze Pin Ng</name><affiliation wicri:level="4"><nlm:aff id="I28">Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Gao, Qi" sort="Gao, Qi" uniqKey="Gao Q" first="Qi" last="Gao">Qi Gao</name><affiliation wicri:level="4"><nlm:aff id="I28">Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Reppermund, Simone" sort="Reppermund, Simone" uniqKey="Reppermund S" first="Simone" last="Reppermund">Simone Reppermund</name><affiliation wicri:level="3"><nlm:aff id="I1">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Brodaty, Henry" sort="Brodaty, Henry" uniqKey="Brodaty H" first="Henry" last="Brodaty">Henry Brodaty</name><affiliation wicri:level="3"><nlm:aff id="I1">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Dementia Collaborative Research Centre, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Dementia Collaborative Research Centre, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Meguro, Kenichi" sort="Meguro, Kenichi" uniqKey="Meguro K" first="Kenichi" last="Meguro">Kenichi Meguro</name><affiliation wicri:level="1"><nlm:aff id="I29">Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Sendai</wicri:regionArea><wicri:noRegion>Sendai</wicri:noRegion></affiliation></author><author><name sortKey="Schupf, Nicole" sort="Schupf, Nicole" uniqKey="Schupf N" first="Nicole" last="Schupf">Nicole Schupf</name><affiliation wicri:level="4"><nlm:aff id="I30">The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I31">The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Gertrude H. Sergievsky Center, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I32">The Division of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Division of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Manly, Jennifer" sort="Manly, Jennifer" uniqKey="Manly J" first="Jennifer" last="Manly">Jennifer Manly</name><affiliation wicri:level="4"><nlm:aff id="I30">The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I31">The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Gertrude H. Sergievsky Center, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I33">The Department of Neurology, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Department of Neurology, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><affiliation wicri:level="4"><nlm:aff id="I30">The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I31">The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Gertrude H. Sergievsky Center, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I33">The Department of Neurology, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Department of Neurology, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Lobo, Antonio" sort="Lobo, Antonio" uniqKey="Lobo A" first="Antonio" last="Lobo">Antonio Lobo</name><affiliation wicri:level="4"><nlm:aff id="I34">Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza</wicri:regionArea><orgName type="university">Université de Saragosse</orgName><placeName><settlement type="city">Saragosse</settlement><region nuts="2" type="region">Aragon (communauté autonome)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I35">Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I36">Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza</wicri:regionArea><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Anton, Raul" sort="Lopez Anton, Raul" uniqKey="Lopez Anton R" first="Raúl" last="Lopez-Anton">Raúl Lopez-Anton</name><affiliation wicri:level="3"><nlm:aff id="I35">Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="I37">Department of Psychology and Sociology, Universidad de Zaragoza, Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychology and Sociology, Universidad de Zaragoza, Zaragoza</wicri:regionArea><orgName type="university">Université de Saragosse</orgName><placeName><settlement type="city">Saragosse</settlement><region nuts="2" type="region">Aragon (communauté autonome)</region></placeName></affiliation></author><author><name sortKey="Santabarbara, Javier" sort="Santabarbara, Javier" uniqKey="Santabarbara J" first="Javier" last="Santabárbara">Javier Santabárbara</name><affiliation wicri:level="3"><nlm:aff id="I35">Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="I38">Department of Preventive Medicine and Public Health, Universidad de Zaragoza, Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Preventive Medicine and Public Health, Universidad de Zaragoza, Zaragoza</wicri:regionArea><orgName type="university">Université de Saragosse</orgName><placeName><settlement type="city">Saragosse</settlement><region nuts="2" type="region">Aragon (communauté autonome)</region></placeName></affiliation></author></analytic><series><title level="j">BMC Neurology</title><idno type="eISSN">1471-2377</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.</p></sec><sec><title>Methods/Design</title><p>Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress.</p></sec><sec><title>Discussion</title><p>The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. 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uniqKey="Wahlund L">LO Wahlund</name></author><author><name sortKey="Nordberg, A" uniqKey="Nordberg A">A Nordberg</name></author><author><name sortKey="Backman, L" uniqKey="Backman L">L Backman</name></author><author><name sortKey="Albert, M" uniqKey="Albert M">M Albert</name></author><author><name sortKey="Almkvist, O" uniqKey="Almkvist O">O Almkvist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carrillo, Mc" uniqKey="Carrillo M">MC Carrillo</name></author><author><name sortKey="Bain, Lj" uniqKey="Bain L">LJ Bain</name></author><author><name sortKey="Frisoni, Gb" uniqKey="Frisoni G">GB Frisoni</name></author><author><name sortKey="Weiner, Mw" uniqKey="Weiner M">MW Weiner</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Corée du Sud</li><li>Espagne</li><li>France</li><li>Japon</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Singapour</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aragon (communauté autonome)</li><li>Communauté de Madrid</li><li>Grand Londres</li><li>Languedoc-Roussillon</li><li>Massachusetts</li><li>Michigan</li><li>Minnesota</li><li>Nouvelle-Galles du Sud</li><li>Occitanie (région administrative)</li><li>Oregon</li><li>Pennsylvanie</li><li>Région capitale de Séoul</li><li>État de New York</li></region><settlement><li>Londres</li><li>Madrid</li><li>Montpellier</li><li>New York</li><li>Pékin</li><li>Saragosse</li><li>Sha Tin</li><li>Sydney</li><li>Séoul</li></settlement><orgName><li>Université Columbia</li><li>Université chinoise de Hong Kong</li><li>Université de Saragosse</li><li>Université nationale de Singapour</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S" last="Sachdev">Perminder S. Sachdev</name></region><name sortKey="Anstey, Kaarin J" sort="Anstey, Kaarin J" uniqKey="Anstey K" first="Kaarin J" last="Anstey">Kaarin J. Anstey</name><name sortKey="Brodaty, Henry" sort="Brodaty, Henry" uniqKey="Brodaty H" first="Henry" last="Brodaty">Henry Brodaty</name><name sortKey="Brodaty, Henry" sort="Brodaty, Henry" uniqKey="Brodaty H" first="Henry" last="Brodaty">Henry Brodaty</name><name sortKey="Butterworth, Peter" sort="Butterworth, Peter" uniqKey="Butterworth P" first="Peter" last="Butterworth">Peter Butterworth</name><name sortKey="Cherbuin, Nicolas" sort="Cherbuin, Nicolas" uniqKey="Cherbuin N" first="Nicolas" last="Cherbuin">Nicolas Cherbuin</name><name sortKey="Crawford, John D" sort="Crawford, John D" uniqKey="Crawford J" first="John D" last="Crawford">John D. Crawford</name><name sortKey="Kochan, Nicole A" sort="Kochan, Nicole A" uniqKey="Kochan N" first="Nicole A" last="Kochan">Nicole A. Kochan</name><name sortKey="Lipnicki, Darren M" sort="Lipnicki, Darren M" uniqKey="Lipnicki D" first="Darren M" last="Lipnicki">Darren M. Lipnicki</name><name sortKey="Reppermund, Simone" sort="Reppermund, Simone" uniqKey="Reppermund S" first="Simone" last="Reppermund">Simone Reppermund</name><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S" last="Sachdev">Perminder S. Sachdev</name></country><country name="Canada"><noRegion><name sortKey="Rockwood, Kenneth" sort="Rockwood, Kenneth" uniqKey="Rockwood K" first="Kenneth" last="Rockwood">Kenneth Rockwood</name></noRegion></country><country name="République populaire de Chine"><noRegion><name sortKey="Xiao, Shifu" sort="Xiao, Shifu" uniqKey="Xiao S" first="Shifu" last="Xiao">Shifu Xiao</name></noRegion><name sortKey="Fung, Ada Wt" sort="Fung, Ada Wt" uniqKey="Fung A" first="Ada Wt" last="Fung">Ada Wt Fung</name><name sortKey="Lam, Linda Cw" sort="Lam, Linda Cw" uniqKey="Lam L" first="Linda Cw" last="Lam">Linda Cw Lam</name><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name><name sortKey="Li, Xia" sort="Li, Xia" uniqKey="Li X" first="Xia" last="Li">Xia Li</name><name sortKey="Wong, Candy Hy" sort="Wong, Candy Hy" uniqKey="Wong C" first="Candy Hy" last="Wong">Candy Hy Wong</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name></noRegion><name sortKey="Matthews, Fiona E" sort="Matthews, Fiona E" uniqKey="Matthews F" first="Fiona E" last="Matthews">Fiona E. Matthews</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Stephan, Blossom Cm" sort="Stephan, Blossom Cm" uniqKey="Stephan B" first="Blossom Cm" last="Stephan">Blossom Cm Stephan</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Lipton, Richard B" sort="Lipton, Richard B" uniqKey="Lipton R" first="Richard B" last="Lipton">Richard B. Lipton</name></region><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><name sortKey="Beiser, Alexa S" sort="Beiser, Alexa S" uniqKey="Beiser A" first="Alexa S" last="Beiser">Alexa S. Beiser</name><name sortKey="Dodge, Hiroko H" sort="Dodge, Hiroko H" uniqKey="Dodge H" first="Hiroko H" last="Dodge">Hiroko H. Dodge</name><name sortKey="Dodge, Hiroko H" sort="Dodge, Hiroko H" uniqKey="Dodge H" first="Hiroko H" last="Dodge">Hiroko H. Dodge</name><name sortKey="Ganguli, Mary" sort="Ganguli, Mary" uniqKey="Ganguli M" first="Mary" last="Ganguli">Mary Ganguli</name><name sortKey="Ganguli, Mary" sort="Ganguli, Mary" uniqKey="Ganguli M" first="Mary" last="Ganguli">Mary Ganguli</name><name sortKey="Ganguli, Mary" sort="Ganguli, Mary" uniqKey="Ganguli M" first="Mary" last="Ganguli">Mary Ganguli</name><name sortKey="Hughes, Tiffany" sort="Hughes, Tiffany" uniqKey="Hughes T" first="Tiffany" last="Hughes">Tiffany Hughes</name><name sortKey="Katz, Mindy J" sort="Katz, Mindy J" uniqKey="Katz M" first="Mindy J" last="Katz">Mindy J. Katz</name><name sortKey="Lipton, Richard B" sort="Lipton, Richard B" uniqKey="Lipton R" first="Richard B" last="Lipton">Richard B. Lipton</name><name sortKey="Manly, Jennifer" sort="Manly, Jennifer" uniqKey="Manly J" first="Jennifer" last="Manly">Jennifer Manly</name><name sortKey="Manly, Jennifer" sort="Manly, Jennifer" uniqKey="Manly J" first="Jennifer" last="Manly">Jennifer Manly</name><name sortKey="Manly, Jennifer" sort="Manly, Jennifer" uniqKey="Manly J" first="Jennifer" last="Manly">Jennifer Manly</name><name sortKey="Mielke, Michelle M" sort="Mielke, Michelle M" uniqKey="Mielke M" first="Michelle M" last="Mielke">Michelle M. Mielke</name><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C" last="Petersen">Ronald C. Petersen</name><name sortKey="Roberts, Rosebud O" sort="Roberts, Rosebud O" uniqKey="Roberts R" first="Rosebud O" last="Roberts">Rosebud O. Roberts</name><name sortKey="Schupf, Nicole" sort="Schupf, Nicole" uniqKey="Schupf N" first="Nicole" last="Schupf">Nicole Schupf</name><name sortKey="Schupf, Nicole" sort="Schupf, Nicole" uniqKey="Schupf N" first="Nicole" last="Schupf">Nicole Schupf</name><name sortKey="Schupf, Nicole" sort="Schupf, Nicole" uniqKey="Schupf N" first="Nicole" last="Schupf">Nicole Schupf</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name></country><country name="France"><noRegion><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name></noRegion><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><name sortKey="Carriere, Isabelle" sort="Carriere, Isabelle" uniqKey="Carriere I" first="Isabelle" last="Carrière">Isabelle Carrière</name><name sortKey="Carriere, Isabelle" sort="Carriere, Isabelle" uniqKey="Carriere I" first="Isabelle" last="Carrière">Isabelle Carrière</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name></country><country name="Corée du Sud"><noRegion><name sortKey="Kim, Ki Woong" sort="Kim, Ki Woong" uniqKey="Kim K" first="Ki Woong" last="Kim">Ki Woong Kim</name></noRegion><name sortKey="Han, Ji Won" sort="Han, Ji Won" uniqKey="Han J" first="Ji Won" last="Han">Ji Won Han</name><name sortKey="Kim, Ki Woong" sort="Kim, Ki Woong" uniqKey="Kim K" first="Ki Woong" last="Kim">Ki Woong Kim</name><name sortKey="Kim, Ki Woong" sort="Kim, Ki Woong" uniqKey="Kim K" first="Ki Woong" last="Kim">Ki Woong Kim</name><name sortKey="Kim, Tae Hui" sort="Kim, Tae Hui" uniqKey="Kim T" first="Tae Hui" last="Kim">Tae Hui Kim</name></country><country name="Singapour"><noRegion><name sortKey="Ng, Tze Pin" sort="Ng, Tze Pin" uniqKey="Ng T" first="Tze Pin" last="Ng">Tze Pin Ng</name></noRegion><name sortKey="Gao, Qi" sort="Gao, Qi" uniqKey="Gao Q" first="Qi" last="Gao">Qi Gao</name></country><country name="Japon"><noRegion><name sortKey="Meguro, Kenichi" sort="Meguro, Kenichi" uniqKey="Meguro K" first="Kenichi" last="Meguro">Kenichi Meguro</name></noRegion></country><country name="Espagne"><region name="Aragon (communauté autonome)"><name sortKey="Lobo, Antonio" sort="Lobo, Antonio" uniqKey="Lobo A" first="Antonio" last="Lobo">Antonio Lobo</name></region><name sortKey="Lobo, Antonio" sort="Lobo, Antonio" uniqKey="Lobo A" first="Antonio" last="Lobo">Antonio Lobo</name><name sortKey="Lobo, Antonio" sort="Lobo, Antonio" uniqKey="Lobo A" first="Antonio" last="Lobo">Antonio Lobo</name><name sortKey="Lopez Anton, Raul" sort="Lopez Anton, Raul" uniqKey="Lopez Anton R" first="Raúl" last="Lopez-Anton">Raúl Lopez-Anton</name><name sortKey="Lopez Anton, Raul" sort="Lopez Anton, Raul" uniqKey="Lopez Anton R" first="Raúl" last="Lopez-Anton">Raúl Lopez-Anton</name><name sortKey="Santabarbara, Javier" sort="Santabarbara, Javier" uniqKey="Santabarbara J" first="Javier" last="Santabárbara">Javier Santabárbara</name><name sortKey="Santabarbara, Javier" sort="Santabarbara, Javier" uniqKey="Santabarbara J" first="Javier" last="Santabárbara">Javier Santabárbara</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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